BOTANICALS
Berberine (extract, 97% berberine HCl)
Berberine is a plant compound that supports healthy glucose metabolism and blood sugar already within the normal range.
Also known as: berberine HCl, berberine hydrochloride, Berberine extract
At a glance
- Form
- Berberine extract · 97% berberine HCl
- Category
- Botanicals
- In an apiece formula
- 1,000 mg a day (you can change it)
- Recommended intake
- No recommended intake (not an essential nutrient)
- Upper limit
- No established UL
- Studied for
- Heart & metabolic health*
- Reference
- NIH ODS: Dietary Supplements, What You Need to Know
Who should be careful
Our safety rules leave berberine out of a formula, or keep the amount lower, with:
Medicines and supplements
- Semaglutide
- Tirzepatide
- Liraglutide, retatrutide or another GLP-1
- Insulin
- SGLT2 inhibitor
- Sulfonylurea or meglitinide
- Other diabetes pills
- Amiodarone or dronedarone
- Other heart-rhythm medicine
- Chemotherapy or targeted cancer pills
- Radiation therapy
- Cancer immunotherapy
- Tamoxifen or toremifene
- HIV integrase inhibitor
- Other HIV medicine or PrEP
Kept to a lower amount with
- Metformin
Health conditions
- Eating disorder, now or recovering
- Arrhythmia
- G6PD deficiency
- Type 1 diabetes
- Type 2 diabetes or prediabetes
Life stage
- Pregnancy
- Breastfeeding
- Trying to conceive
Always check with your doctor or pharmacist before adding a supplement if you take medication, are pregnant or nursing, or have a health condition. Stay under the upper limit from all sources combined, including multivitamins.
Symptoms it’s studied for
- Tired or low energy
- Afternoon crash
- Brain fog or poor focus
- Poor sleep
- Skin issues (acne, dry, eczema)
- Sugar cravings
Questions
How much berberine a day?
apiece formulas usually include 1,000 mg a day. The recommended intake for adults is No recommended intake (not an essential nutrient). Upper limit: No established UL.
What is berberine used for?
Berberine is a plant compound that supports healthy glucose metabolism and blood sugar already within the normal range. In apiece it is part of formulas for Heart & metabolic health.*
Who should be careful with berberine?
apiece’s safety rules leave it out or limit it with: Semaglutide; Tirzepatide; Liraglutide, retatrutide or another GLP-1; Insulin; SGLT2 inhibitor; Sulfonylurea or meglitinide; Other diabetes pills; Amiodarone or dronedarone; Other heart-rhythm medicine; Chemotherapy or targeted cancer pills and others. Check with your doctor or pharmacist if any apply to you.
Can I get berberine in a personalized supplement?
Yes. apiece builds one daily blend around your goals and, if you have them, your lab results. Berberine can be part of it at the amount listed, with every ingredient shown and never more than 10 capsules a day.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This page is general information, not medical advice. Check with your doctor or pharmacist before starting a supplement, especially if you take medication, are pregnant or nursing, or have a health condition. Updated 2026-10-21.